Yeah speed is TBD ...
For Space, I did a bit of testing for area and with a fairly regular rom content, the gain isn't huge, maybe only 30% smaller (because synthesis managed to optimize quite a bit), but it still have like 17 gate logic depth. Also this was with the OSS tools which barely manage a 50% density. While using hand placement here I have 95+% density. With random ROM content, the gain was way more substantial.
Then of course all that synth opt would prevent any hope of updating the ROM content without re-running the flow. And given how difficult it was in the first shuttle to get a GDS out, the ability to change microcode rom, boot rom, character rom, etc ... without going through all that again (in what we submitted I needed quite a few manual edits after the run, so that's like 3-4 hours of manual work at each rebuilt, everytime with the potential of screwing up).