S parameters are linear models of the reflection of a n-port device over frequency. The skywater PDK has BSIM models which model the device through differential equations.
If you want to simulate s-parameters you need to create a spice simulation with a certain device size (W, L, M, nf) and bias (Ids, Vds, Vbs) to extract the scattering parameters. Once you have these values as a table of text you can create a touchstone file that can be read by Qucs s-parameter file read.
It's possible to do all this inside Qucs but you need to use the ngspice (or Xyce) backend to exteact the s-parameters