I'm using five different macros with different configurations in my digital design. Is it possible to have the same set of GPIO inputs and outputs (io_in[35:0] and io_out[35:0]) for all the macros? Also, the macros are NOT interconnected with each other. Thanks.

You can distribute the

io_in

to as many subcells as you want. For

io_out

you will want to multiplex between the macros. @Matt Venn has done something very similar with multiple macros in the user area all sharing the I/O through multiplexing.

Thank you, I will check with Matt.