Nobody can help without details. What exactly are you trying to do?
I have tested and a node can be named 2M<whatever> and works just fine.
If you are using it as a number consider that for spice 2M = 2milli = 0.002
If you want Mega you need to use 2MEG
As a general rule I suggest using for node names identifiers starting with an alphabetic character.
a node named 2MCLK will work in spice but will definitely not work in Verilog or VHDL, as these languages prohibit using identifier starting with a number. for example in Verilog: