@Guilherme Ferrara Sorry, let me clarify. I haven’t heard anything about openlane being able to synthesize standard cell logic designs with different power domains (or different libraries). I may be wrong though.
Openlane can route hard macros that have different power domains or different libraries.
For example, you could create a hard macro of level shifters, and have openlane synthesize 1.8V logic and connect it’s output signals to the level shifter inputs. You could also have openlane route the outputs, but you need to be careful that 1.8V buffers are not inserted on 3.3V signals.