I don't think my tools (magic, netgen, open_pdks) are going to give you any issues. Xschem and ngspice should be good, too; none of the foregoing uses anything but well-established dependencies. I can't speak for klayout, Xyce, or OpenROAD. I do, however, have a set of instructions for installing everything under Mac OS. Have you seen it? The location is here: https://docs.google.com/document/d/1QXi2kqWgQ8JR_BJCfUgFkQCSSxetXcnWrDHRJdLBsy0/edit. In particular, see Appendix 3. Also check out JKU-IIC tools at https://github.com/iic-jku/IIC-OSIC-TOOLS. Thread in Slack Conversation