Hi
@Alex Mantilla, you can run LVS in KLayout.
Make sure you have the latest KLayout package installed, either via the builtin package manager or your PDK installation:
https://github.com/efabless/sky130_klayout_pdk
If you select "sky130" as technology you should see the "Efabless sky130" menu in the top bar. There you can select "Run LVS" and choose your schematic file.
Unfortunately, KLayout expects primitive devices and not subcircuits in the spice file. Therefore you need to export your schematic netlist without the X prefixes.
I have a tutorial here, some of the content is still valid:
https://codeberg.org/mole99/klayout-sky130-inverter
As for pex, this is currently not possible with KLayout for sky130. But this may change in the near future.
If you have any issues, feel free to ask questions.